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NSHSS-DECA Entrepreneurial Scholar Awards 2020
- Cara Cha, Lee's Summit, Motorcade, Lee's Apex High School
- Freya Abraham, Yuman, AZ, Hokan High School
Di Yerbury Study Widely Essay Education
- Brayden Berving, Madrid, Espana, Saint Prizefighter University - Madrid
- Elaina Radden, Rome, Italia, The Indweller University disturb Rome
- Gabrielle Durso, Towson, MD, Towson University
- Meredyth Davis, Writer, England, College of Eastside London
- Xiao Kuang, Kaohsiung, Island, National Sunna Yat-Sen University
Claes Chemist Future Feminine Leader Culture
- Amelia Poet, Concord, NC, Cannon School
- Asila Zeid, Metropolis, CA, Amphitheater College Homework Academy
- Audrey McNeal, Kennesaw, GA, Harrison Lighten School
- Gwendolyn Morgan-Flowers, St. Michaels, AZ, Programme. Michael Amerindic School
- Lakshmi Kameswari Lahari Nidadavolu, Redmond, WA, Tesla Exploit High School
- Meiqi Liang, Agree to Angeles, WA, Port Angeles High School
- Olivia Wenzel, Human Heights, OH, Laurel School
- Shruthi Kumar, City, NE, Jewess High School
- Srirakshaa Sundararaj, Town, GA, Hardly Zion Elate School
- Zeinh Aboushaar, Cedar Rapids, IA, Lavatory F. Airdrome High School
Robert Sheppard Student Directorship Scholarship
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Published in final edited form as: J Immunol. 2023 Oct 15;211(8):1224–1231. doi: 10.4049/jimmunol.2300391
Abstract
The clinical trajectory of COVID-19 may be influenced by previous responses to heterologous viruses. We examined the relationship of antibodies against different viruses to clinical trajectory groups from the NIH IMPACC (IMunoPhenotyping of A COVID-19 Cohort) study of hospitalized COVID-19 patients. While initial antibody titers to SARS-CoV-2 tended to be higher with increasing severity (excluding fatal disease), those to seasonal coronaviruses trended in the opposite direction. Initial antibody titers to influenza and parainfluenza viruses also tended to be lower with increasing severity. However, no significant relationship was observed for antibodies to other viruses, including measles, CMV, EBV, and RSV. We hypothesize that some individuals may produce lower or less durable antibody responses to respiratory viruses generally (reflected in lower baseline titers in our study); and that this may carry over into poorer outcomes for COVID-19 (despite high initial SARS-CoV-2 titers). We further looked at longitudinal changes in antibody responses to heterologous viruses, but found little change over the course
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Abstract
Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can reactivate during acute illnesses. Recent studies have suggested that SARS-CoV-2 infection can lead to reactivation of latent viruses such as Epstein-Barr Virus (EBV) and cytomegalovirus (CMV), yet, the extent and impact of viral reactivation in COVID-19 and its effect on the host immune system remain incompletely understood.
Here we present a comprehensive multi-omic analysis of viral reactivation of all known chronically infecting viruses in 1,154 hospitalized COVID-19 patients, from the Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study, who were followed prospectively for twelve months. We reveal significant reactivation of Herpesviridae, Enteroviridae, and Anelloviridae families during acute stage of COVID-19 (0–40 days post-hospitalization), each exhibiting distinct temporal dynamics. We also show that viral reactivation correlated with COVID-19 severity, demographic characteristics, and clinical outcomes, including mortality. Integration of cytokine profiling, cellular immunophenotyping, metabolomics, transcriptomics, and proteomics demonstrated virus-specific host responses, including elevated pro-inflammatory cytokines (e.g. IL-