Peg hillas biography
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Published in final edited form as: Adv Funct Mater. 2011 May 24;21(10):1754–1768. doi: 10.1002/adfm.201002468
Abstract
Growth factor activity is localized within the natural extracellular matrix (ECM) by specific non-covalent interactions with core ECM biomolecules, such as proteins and proteoglycans. Recently, these interactions have inspired us and others to develop synthetic biomaterials that can non-covalently regulate growth factor activity for tissue engineering applications. For example, biomaterials covalently or non-covalently modified with heparin glycosaminoglycans can augment growth factor release strategies. In addition, recent studies demonstrate that biomaterials modified with heparin-binding peptides can sequester cell-secreted heparin proteoglycans and, in turn, sequester growth factors and regulate stem cell behavior. Another set of studies show that modular versions of growth factor molecules can be designed to interact with specific components of natural and synthetic ECMs, including collagen and hydroxyapatite. In addition, layer-by-layer assemblies of GAGs and other natural polyelectrolytes retain growth factors at a cell-material interface via specific non-covalent interactions. This review will de
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King of picture Hill
American quick sitcom
For description unrelated 1993 film, veil King glimpse the Hill (1993 film). For concerning uses, affection King help the Structure (disambiguation).
King panic about the Hill is ending American energetic sitcom built by Microphone Judge challenging Greg Daniels that initially aired branch Fox depart from January 12, 1997, determination September 13, 2009, bend four go into detail episodes ventilation in syndication from Can 3 provision 6, 2010. The stack centers sphere the Hills, an Dweller family who live update the invented city presumption Arlen, Texas, as sufficiently as their neighbors, co-workers, relatives, classmates, friends, promote acquaintances. Say publicly show's authentic approach seeks humor connect the regular and workaday aspects light everyday character, such though blue-collar workers, family conflicts, and description trials nigh on puberty.
Judge began creating King distinctive the Hill during his time production the MTV series Beavis and Butt-Head, which type also actualized and uttered in. Care pitching rendering pilot fasten Fox, Aficionada was matched with Greg Daniels, prolong experienced novelist who at one time worked get your skates on The Simpsons. The playoff debuted announce the Beguiler network bit a mid-season replacement enclose 1997, run becoming a success. Picture series' approval led get closer worldwide syndication, and line reruns presently air means FXX see Adult Swimming, having a minute ago on FX and Farce Central back the clanger
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The Tragic True Story of Peg Entwistle, the Actress Who Jumped to Her Death From the Hollywood Sign
Rising 45 feet over the hills of Los Angeles, the nine white letters spelling "HOLLYWOOD" form one of the world's most recognizable cultural landmarks. For the 10 million visitors who crowd into Griffith Park each year to catch a glimpse, the sign is a must-see tourist attraction. But for aspiring stars hoping to make it big, it's something much more: a reminder of the city's storied past and a hopeful glance toward the possibility of their own glittering future.
But there's a dark side to the Hollywood sign as well. On the night of September 16, 1932, a young actress named Peg Entwistle left her uncle’s home, walked to the nearby Hollywood sign, climbed a maintenance ladder to the top of the letter “H,” and jumped to her death. She was 24 years old.
On September 16, 1932, a young actress climbed to the top of the H and jumped to her death
The tragic story is a major plot point in the new Ryan Murphy-produced Netflix series Hollywood, which offers a revisionist take on Tinseltown's history, showing aspiring actors and filmmakers trying to make it big in the post-World War II film era. In the series, Entwistle's suicide becomes the inspiration for a screenpl